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| Caption | Autoimmune disease in mutant mice. (A) Splenomegaly and lymphadenopathy observed in both Mir146tm1.1Bal/Mir146tm1.1Bal and Mir146tm2.1Bal/Mir146tm2.1Bal mice. Photographs of spleens and peripheral lymph nodes removed from a single representative wild-type (WT) and knockout (KO) mouse. (D) Multiorgan inflammation in homozygous mutant mice. Hematoxylin- and eosin-stained sections of liver and kidney from WT (top) and mutant (middle, low magnification; bottom, high magnification) mice. Note the leukocytic infiltrates in the KO liver (circled with dashed lines), compared with a relatively spared portal triad (PT) in the WT liver. At higher magnification, degenerated hepatocytes (marked by arrows) displaying fragmented nuclei and eosinophilic cytoplasm indicate tissue damage caused by the inflammatory infiltrates. Note the large infiltrate of inflammatory cells (circled) in the mutant kidney. In the low-power image, the KO tubules appear more eosinophilic, and their lumina are dilated. At higher magnification, a degenerated tubule (marked by arrows) indicates tissue damage caused by the inflammatory infiltrates. Bars: (top and middle) 200 um; (bottom) 40 um. | ||||||
| Copyright | This image is from Boldin MP, J Exp Med 2011 Jun 6;208(6):1189-201, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:173671 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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