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| Caption | A and B, focal plane by three-dimensional reconstruction of isolectin B4 (IB4, blue) staining in Angptl4tm1Vlcg/Angptl4+ (angptl4+/LacZ) and Angptl4tm1Vlcg/Angptl4tm1Vlcg (angptl4LacZ/LacZ) retinas. ZO-1 (TJP1, red) (C and D) and VE-CAD (CDH5, green) (E and F) staining reveals discontinuous endothelial junctions in area 2 of homozygous mutant vasculature (the arrows point to discontinuous junctions at branch points and the arrowheads indicate tortuous-like junctions (D and F). Scale bar=15um. G and H, schematic representation of the endothelial surface of IB4 staining (blue) and endothelial junctions of VE-CAD and ZO-1 staining (light blue tracing). Endothelial junctions are poorly developed in Angptl4tm1Vlcg/Angptl4tm1Vlcg capillaries (H) compared with mature junctions in control retinas (G). | ||||
| Copyright | This image is from Perdiguero EG, J Biol Chem 2011 Oct 21;286(42):36841-51 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:177790 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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