Phenotype Image Detail

Image

Caption

Simultaneous deletion of Smad2 and Ppm1a accelerates re-epithelialization rate. B, K14 (brown) immunostaining of the sections of wounded skin in Tg(KRT5-cre)1Xya/0 Smad2^tm1Xya/Smad2^tm1Xya Ppm1a^tm1.1Xya/Ppm1a^tm1.1Xya (K5-Cre;Smad2^fl/fl;Ppm1a^-/-) mice and control (Smad2^fl/+;Ppm1a^+/-) mice at day 3 after injury. Arrows indicated the leading edges of wounded epidermis.

This image is from Yang X, J Biol Chem 2011 Dec 9;286(49):42267-73 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:178733

Associated
Alleles

Symbol	Name
Ppm1a^tm1.1Xya	protein phosphatase 1A, magnesium dependent, alpha isoform; targeted mutation 1.1, Xiao Yang
Smad2^tm1Xya	SMAD family member 2; targeted mutation 1, Xiao Yang
Tg(KRT5-cre)1Xya	transgene insertion 1, Xiao Yang

Associated
Genotypes

Allelic Composition	Genetic Background
Ppm1a^tm1.1Xya/Ppm1a^tm1.1Xya Smad2^tm1Xya/Smad2^tm1Xya Tg(KRT5-cre)1Xya/0	involves: 129S6/SvEvTac * FVB/N

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