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Phenotype Image Detail
Image
Caption A, immunohistochemical detection of the striatal tyrosine hydroxylase (TH) and dopamine (DA) in the striatum of the Thtm1.1Ich/Thtm1.1Ich (Thfl/fl) mouse. The mice were fixed with glutaraldehyde 8 weeks after the injection of AAV-GFP/Cre, and the slices cut with a vibratome were stained with antibodies against TH or dopamine. Note thta the TH signal in the injected side (Inj) was descreased compared with the uninjected side (Uninj), whereas the DA signal was less affected. B, magnification images of the regions indicated by asterisks in A, showing TH-expressing axon fibers and dopamine-containing axonal boutons. Arrowheads indicate representative puncta of the dopamine signals. Scale bars, 0.5 mm (A) and 10 um (B).
Copyright This image is from Tokuoka H, J Biol Chem 2011 Dec 16;286(50):43549-58 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:178698
Associated
Alleles
Symbol Name
Thtm1.1Ich tyrosine hydroxylase; targeted mutation 1.1, Hiroshi Ichinose
Associated
Genotypes
Allelic Composition Genetic Background
Thtm1.1Ich/Thtm1.1Ich Not Specified

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory