Phenotype Image Detail

Image

Caption

Histological sections from central and peripheral retinas of 4-week-old Rpe65^rd12/Rpe65^rd12 (Rpe65^rd12/rd12;Rho^+/+) and Rpe65^rd12/Rpe65^rd12 Rho^Tvrm4/Rho⁺ (Rpe65^rd12/rd12;Rho^Tvrm5/+) animals, n=3 mice. At 4 weeks of age, retinas of Rpe65^rd12/Rpe65^rd12 mice retained a full complement of photoreceptor nuclei. In comparison, Rpe65^rd12/Rpe65^rd12 Rho^Tvrm4/Rho⁺ mutants had only 2-3 rows of cell bodies remaining in the central ONL. The peripheral retina that also showed cell loss was better preserved than the central retina.

This image is from Budzynski E, J Biol Chem 2010 May 7;285(19):14521-33 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:159523

Associated
Alleles

Symbol	Name
Rho^Tvrm4	rhodopsin; translational research vision model 4
Rpe65^rd12	retinal pigment epithelium 65; retinal degeneration 12

Associated
Genotypes

Allelic Composition	Genetic Background
Rho^Tvrm4/Rho⁺ Rpe65^rd12/Rpe65^rd12	B6.Cg-Rpe65^rd12 Rho^Tvrm4

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