Phenotype Image Detail

Image

Caption

Ablation of medium-spiny projection neurons in the striatum of Gng7^{tm2(cre/PGR)Mmsh}/Gng7⁺ Eno2^tm1(DTA)Hsak/Eno2⁺ (mutant) mice. A, Immunoreactivity for calbindin in the dorsal striatum of control (upper) and Gng7^{tm2(cre/PGR)Mmsh}/Gng7⁺ Eno2^tm1(DTA)Hsak/Eno2⁺ (lower) mice. B, Immunoreactivity for tyrosine hydroxylase and substance P in substantia nigra of control and mutant mice. Abbreviations: CP, caudate putamen; GP, globus pallidus; SNc, substantia nigra pars compacta; SNr, substantia nigra pars reticulata; VTA, ventral tegmental area. Scale bars, 1 mm.

This image is from Kishioka A, PLoS ONE 2009;4(1):e4157, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:145152

Associated
Alleles

Symbol	Name
Eno2^tm1(DTA)Hsak	enolase 2, gamma neuronal; targeted mutation 1, Hitoshi Sakno
Gng7^{tm2(cre/PGR)Mmsh}	guanine nucleotide binding protein (G protein), gamma 7; targeted mutation 2, Masayoshi Mishina

Associated
Genotypes

Allelic Composition	Genetic Background
Eno2^tm1(DTA)Hsak/Eno2⁺ Gng7^{tm2(cre/PGR)Mmsh}/Gng7⁺	involves: C57BL/6

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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