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Phenotype Image Detail
Image
Caption Ror1tm1.1Meg/Ror1tm1.1Meg Ror2tm1.1Meg/Ror2tm1.1Meg H2az2Tg(Wnt1-cre)11Rth/0 (Ror1f/f;Ror2fl/fl Wnt1-Cre) embryos exhibit sympathetic axon branching defects. (D-I) TH immunostaining in E17.5 control heterozygous (Ror1f/+;Ror2f/+) spleen (D), kidney (E), and bladder (F) and littermate E17.5 double homozygous mutant spleen (G), kidney (H), and bladder (I). Arrows denote axonal branches that are normally seen in control target organs but are compromised in mutant target organs. (J and K) Sympathetic chain ganglia of the double homozygous embryos appear grossly intact and show normal coalescence as shown by whole-mount TH staining.
Copyright This image is from Ho HY, Proc Natl Acad Sci U S A 2012 Mar 13;109(11):4044-51. Copyright 2012 National Academy of Sciences, U.S.A. J:182150
Associated
Alleles
Symbol Name
H2az2Tg(Wnt1-cre)11Rth H2A.Z histone variant 2; transgene insertion 11, David H Rowitch
Ror1tm1.1Meg receptor tyrosine kinase-like orphan receptor 1; targeted mutation 1.1, Michael E Greenberg
Ror2tm1.1Meg receptor tyrosine kinase-like orphan receptor 2; targeted mutation 1.1, Michael E Greenberg
Associated
Genotypes
Allelic Composition Genetic Background
Ror1tm1.1Meg/Ror1tm1.1Meg
Ror2tm1.1Meg/Ror2tm1.1Meg
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: 129S4/SvJae * C57BL/6J * CBA/J
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory