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Phenotype Image Detail
Image
Caption Effect of mammary epithelial Src deletion on tumorigenesis in Tg(MMTV-PyVT)#Mul/0 mice. (B) Representative whole mounts of inguinal mammary glands from 8-wk-old virgin Tg(MMTV-PyVT)#Mul/0 Tg(MMTV-cre)7Mul/0 (PyVmT/Cre/c-Src+/+) controls (n = 7), Tg(MMTV-PyVT)#Mul/0 Tg(MMTV-cre)7Mul/0 Srctm1Mul/Src+ (PyVmT/Cre/c-Src+/L) (n = 5), and Tg(MMTV-PyVT)#Mul/0 Tg(MMTV-cre)7Mul/0 Srctm1Mul/Srctm1Mul (PyVmT/Cre/c-SrcL/L) (n = 7) mice. The average mass +/- SEM is indicated below each image (**P < 0.01, unpaired Student t test vs. WT).
Copyright This image is from Marcotte R, Proc Natl Acad Sci U S A 2012 Feb 21;109(8):2808-13. Copyright 2012 National Academy of Sciences, U.S.A. J:181822
Associated
Alleles
Symbol Name
Srctm1Mul Rous sarcoma oncogene; targeted mutation 1, William J Muller
Tg(MMTV-cre)7Mul transgene insertion 7, William J Muller
Tg(MMTV-PyVT)#Mul transgene insertion, William J Muller
Associated
Genotypes
Allelic Composition Genetic Background
Srctm1Mul/Src+
Tg(MMTV-cre)7Mul/0
Tg(MMTV-PyVT)#Mul/0 		involves: 129S1/Sv * 129X1/SvJ * FVB/N
Srctm1Mul/Srctm1Mul
Tg(MMTV-cre)7Mul/0
Tg(MMTV-PyVT)#Mul/0 		involves: 129S1/Sv * 129X1/SvJ * FVB/N
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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10/29/2024
MGI 6.24 		The Jackson Laboratory