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| Caption | Histological and histomorphometric analysis of wild-type (+/+), Cd68tm1Xfen/Cd68+ (-/+), and Cd68tm1Xfen/Cd68tm1Xfen (-/-) mice. (A) Representative formalin-fixed, paraffin-embedded histological sections from each genotyped stained for TRAP activity and counterstained with hematoxylin at 40X magnification. (B) 400X magnification of area defined in (A). (C) Quantification of number of osteoclasts per bone surface (N, OC/BS). There was no significant difference in N. OC/BS between genotypes. (D) Representative 70% ethanol-fixed, plastic-embedded histological sections from each genotype stained with Goldner's trichrome at 40X magnification. (E) 400X magnification of area defined in (D). (F) Histomorphometric analysis of trichrome-stained sections. There was no significant difference between genotypes in numbers of osteoblasts (N. OB/BS) per bone surface. There was a significant increase in bone volume per total volume (BV/TV) in Cd68tm1Xfen/Cd68tm1Xfen mice compared to wild-type animals and trabecular number (N. Tb.) in homozygous mutant mice compared to wild-type and heterozygous mutant animals. (G) Quantification of mineral apposition rate (MAR) via analysis of calcein double labeling. The MAR was significantly higher in homozygous mutant mice compared to both wild-type and heterozygous mutant animals, and MAR was significantly higher in heterozygous mice compared to wild-type animals. *, p<.05; **, p<.01. Data presented are means + standard deviation. | ||||||
| Copyright | This image is from Ashley JW, PLoS One 2011;6(10):e25838, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:178120 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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