Phenotype Image Detail

Image

Caption

Histological analysis of Capns1^tm1.1Otsu/Capns1^tm1.1Otsu Tg(Myh6-cre)2182Mds/0 (Capns1-/-) hearts 7 days after transverse aortic constriction (TAC). A, hematoxylin/eosin-stained heart sections. Scale bars = 25 um. B, cardiomyocyte cross-sectional area measured in the sections in A. Open and closed bars represent sham- and TAC-operated groups, respectively. Values are expressed as the mean +/-S.E. *, p<0.05 versus the corresponding sham-operated group. C, Azan-Mallory stained heart sections. Quantification of fibrotic area is shown in the graph. Scale bars = 100 um. Open and closed bars represent sham- and TAC-operated groups, respectively. Values are expressed as the mean +/-S.E. *, p<0.05 versus all other groups.

This image is from Taneike M, J Biol Chem 2011 Sep 16;286(37):32170-7 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:176736

Associated
Alleles

Symbol	Name
Capns1^tm1.1Otsu	calpain, small subunit 1; targeted mutation 1.1, Kinya Otsu
Tg(Myh6-cre)2182Mds	transgene insertion 2182, Michael D Schneider

Associated
Genotypes

Allelic Composition	Genetic Background
Capns1^tm1.1Otsu/Capns1^tm1.1Otsu Tg(Myh6-cre)2182Mds/0	involves: C57BL/6J * FVB/N

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