Phenotype Image Detail

Image

Caption

Microcomputed tomography (microCT) reconstructions of the spinal column, pelvis, knee, femur, and tibia of a wild-type (GR+/+) and an affected Akr1a1^{Gt(OST222400)Lex}/Akr1a1^{Gt(OST222400)Lex} (GR-/-) (189-day-old female). Carcasses were scanned at 36 um in a Scanco microCT 40 with a threshold value of 240. Note the mineral disappearance in the mutant bones as compared with the wild-type and dissolution of the patella and numerous fractures (arrows) in the long bones.

This image is from Gabbay KH, J Biol Chem 2010 Jun 18;285(25):19510-20 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:164548

Associated
Alleles

Symbol	Name
Akr1a1^{Gt(OST222400)Lex}	aldo-keto reductase family 1, member A1; gene trap OST222400, Lexicon Genetics

Associated
Genotypes

Allelic Composition	Genetic Background
Akr1a1^{Gt(OST222400)Lex}/Akr1a1^{Gt(OST222400)Lex}	B6.129S5-Akr1a1^{Gt(OST222400)Lex}

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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