Phenotype Image Detail

Image

Caption

Increased cardiac neutrophil accumulation of Timp4^tm1Vuo/Timp4^tm1Vuo mice post-myocardial infarction is normalized by ablation of Mmp2. A, neutrophil staining of wild-type, Timp4^tm1Vuo/Timp4^tm1Vuo (Timp4-/-), and double knock-out Timp4^tm1Vuo/Timp4^tm1Vuo Mmp2^tm1Ito/ Mmp2^tm1Ito (Timp4-/-Mmp2-/-) cardiac tissue at 3 days following myocardial infarction. Scale bar, 50um.

This image is from Koskivirta I, J Biol Chem 2010 Aug 6;285(32):24487-93 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:165901

Associated
Alleles

Symbol	Name
Mmp2^tm1Ito	matrix metallopeptidase 2; targeted mutation 1, Shigeyoshi Itohara
Timp4^tm1Vuo	tissue inhibitor of metalloproteinase 4; targeted mutation 1, Eero Vuorio

Associated
Genotypes

Allelic Composition	Genetic Background
Timp4^tm1Vuo/Timp4^tm1Vuo	involves: 129S7/SvEvBrd * C57BL/6
Mmp2^tm1Ito/Mmp2^tm1Ito Timp4^tm1Vuo/Timp4^tm1Vuo	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

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