Phenotype Image Detail

Image

Caption

(a)-(d) H&E staining of transverse cross sections through cardiotoxin (CTX)-injured tibialis anterior (TA) muscles 5 days post injection from wild-type (a) and (c) and Trim32^tm1Hdin/Trim32^tm1Hdin (b) and (d) mice. (c) and (d) show enlarged regions of the boxed areas in (a) and (b), respectively. (e)-(h). H&E staining of transverse cross sections through CTX-injured TA muscles 16 days post injection from wild-type (e) and (g) and mutant (f) and (h) mice. (g) and (h) show enlarged regions of (e) and (f), respectively. Arrow in (g) indicates centrally nucleated myofiber characteristic of efficient muscle regeneration in wild-type TA. In contrast, some regions of injured mutant TA display small centrally nucleated myofibers (h, arrowhead), adipocyte-like cells (f, arrow) or fibrosis (h, arrow).

This image is from Nicklas S, PLoS One 2012;7(1):e30445, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:184218

Associated
Alleles

Symbol	Name
Trim32^tm1Hdin	tripartite motif-containing 32; targeted mutation 1, Hao Ding

Associated
Genotypes

Allelic Composition	Genetic Background
Trim32^tm1Hdin/Trim32^tm1Hdin	involves: 129S1/Sv

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