Phenotype Image Detail

Image

Caption

(A) The 4-week-old Fam20c^tm1.1Cqi/Fam20c^tm1.1Cqi Edil3^{Tg(Sox2-cre)1Amc}/0 (cKO) mouse on the left was smaller compared with the wild-type (WT) littermate on the right. (B) The 4-week-old mutant mouse (left) had flat face (undeveloped nose, a typical manifestation of rickets) compared with the WT littermate (right). (C) Body weight monitoring from newborn (Nb) to postnatal 10 weeks revealed significant growth retardation in the mutant mice. (D) Plain X-ray examination of a 5-month-old mutant mouse (left) revealed smaller skeleton, hypomineralization and distorted spine (arrowheads) compared with its WT littermate (right).

This image is from Wang X, PLoS Genet 2012 May;8(5):e1002708, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:185208

Associated
Alleles

Symbol	Name
Edil3^{Tg(Sox2-cre)1Amc}	EGF-like repeats and discoidin I-like domains 3; transgene insertion 1, Andrew P McMahon
Fam20c^tm1.1Cqi	FAM20C, golgi associated secretory pathway kinase; targeted mutation 1.1, Chunlin Qin

Associated
Genotypes

Allelic Composition	Genetic Background
Fam20c^tm1.1Cqi/Fam20c^tm1.1Cqi Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺	involves: 129S6/SvEvTac * C57BL/6 * CBA

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