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Caption | Rgs7tm1Cjch/Rgs7tm1Cjch Rgs11tm1Lex/Rgs11tm1Lex double knock-out (DKO) mice have no electroretinogram (ERG) b-waves and contain ultrastructural defects in the retinal outer plexiform layer (OPL). A, representative scotopic ERG responses from 2-month-old wild-type control and double knock-out (DKO) mice with flash intensity indicated at left in units of log cd sm-2. B, immunohistochemical staining of control and mutant retinal sections for CtBP2 (1:2,000, white) and PKCalpha (1:100,000, red) demonstrating reduction in rod bipolar cell dendritic arborization. BV, blood vessel. Scale bar, 5 um. C, representative transmission electron microscopic images of the OPL from control and mutant mice. Scale bar, 2 um. RS, rod spherule. Asterisk denotes abnormal structure. D and E, percentage of rod spherules with normal synaptic triads (D) and ribbons (E) in the mutant (n=4, 80 images) versus control (n=3, 65 images) retinas (*, p< 0.01). Error bars are S.D. | ||||||
Copyright | This image is from Shim H, J Biol Chem 2012 Apr 27;287(18):14873-9 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:184922 | ||||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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