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| Caption | (A) Table showing the frequency of cardiac abnormalities identified in Gata4tm1Grg/Gata4+ (Gata4 G295Ski/wt) mice (n = 9) and wild-type littermates (n = 12). Representative images of color (B, D, E, I, J) and pulsed wave Doppler (C, F, G, K, L) findings are shown. Small atrial communication demonstrated by both (B) color and (C) pulsed wave Doppler in heterozygous mutant mouse. Color Doppler recordings across normal aortic valve of a wild-type mouse (D) and stenotic aortic valve of heterozygous mutant mouse (E). Pulsed Doppler waveforms of flow across the aortic valve in wild-type (F) and heterozygous mutant (G) mice demonstrate increased aortic velocity in mutant mice. (H) Scatter plot showing aortic velocities in wild-type and heterozygous mutant mice. Four mutant mice with aortic stenosis are indicated in red. Color Doppler recordings across pulmonary valve of a wild-type (I) and stenotic pulmonary valve in mutant mice (J). Pulsed Doppler waveforms across pulmonary valve of wild-type (K) and mutant mice (L) show increased velocity in mutant mice. (M) Scatter plot showing velocity across pulmonary valve in wild-type and mutant mice. Two mutant mice with pulmonary stenosis indicated in red. | ||||
| Copyright | This image is from Misra C, PLoS Genet 2012 May;8(5):e1002690, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:185124 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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