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Phenotype Image Detail
Image
Caption (C) Mouse embryonic fibroblasts (MEFs) infected with vector control or Cre were left in full medium or serum starved for 6 hours and observed by EM. Large-sized empty vacuoles are observed in Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi null MEFs representing single-membraned swollen endosomes/lysosomes. Serum starvation induced the appearance of autophagosomes in wild-type, but not Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi null MEFs. Quantification of the number of autophagosomes was obtained by counting 10-20 cells and the averages +/- SEM are shown.
Copyright This image is from Jaber N, Proc Natl Acad Sci U S A 2012 Feb 7;109(6):2003-8. Copyright 2012 National Academy of Sciences, U.S.A. J:182628
Associated
Alleles
Symbol Name
Pik3c3tm1c(EUCOMM)Wtsi phosphatidylinositol 3-kinase catalytic subunit type 3; targeted mutation 1c, Wellcome Trust Sanger Institute
Associated
Genotypes
Allelic Composition Genetic Background
Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi involves: C57BL/6N
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory