About   Help   FAQ
Phenotype Image Detail
Image
Caption (C) Mouse embryonic fibroblasts (MEFs) infected with vector control or Cre were left in full medium or serum starved for 6 hours and observed by EM. Large-sized empty vacuoles are observed in Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi null MEFs representing single-membraned swollen endosomes/lysosomes. Serum starvation induced the appearance of autophagosomes in wild-type, but not Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi null MEFs. Quantification of the number of autophagosomes was obtained by counting 10-20 cells and the averages +/- SEM are shown.
Copyright This image is from Jaber N, Proc Natl Acad Sci U S A 2012 Feb 7;109(6):2003-8. Copyright 2012 National Academy of Sciences, U.S.A. J:182628
Associated
Alleles
Symbol Name
Pik3c3tm1c(EUCOMM)Wtsi phosphatidylinositol 3-kinase catalytic subunit type 3; targeted mutation 1c, Wellcome Trust Sanger Institute
Associated
Genotypes
Allelic Composition Genetic Background
Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi involves: C57BL/6N
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
07/05/2024
MGI 6.24 		The Jackson Laboratory