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Phenotype Image Detail
Image
Caption (C) Livers isolated from mice with indicated genotypes, Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi (f/f;Alb-Cre-) and Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi Speer6-ps1Tg(Alb-cre)21Mgn/0 (f/f:Alb-Cre+), were stained with hematoxylin and eosin (H&E), Oil Red O, or Periodic Acid Schiff (PAS). Representative images are shown. Mutant livers show presence of intracellular vacuolation (H&E), accumulation of lipids (Oil Red O), and lack of glycogen deposits (PAS).
Copyright This image is from Jaber N, Proc Natl Acad Sci U S A 2012 Feb 7;109(6):2003-8. Copyright 2012 National Academy of Sciences, U.S.A. J:182628
Associated
Alleles
Symbol Name
Pik3c3tm1c(EUCOMM)Wtsi phosphatidylinositol 3-kinase catalytic subunit type 3; targeted mutation 1c, Wellcome Trust Sanger Institute
Speer6-ps1Tg(Alb-cre)21Mgn spermatogenesis associated glutamate (E)-rich protein 6, pseudogene 1; transgene insertion 21, Mark A Magnuson
Associated
Genotypes
Allelic Composition Genetic Background
Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: C57BL/6 * C57BL/6N * DBA
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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10/29/2024
MGI 6.24 		The Jackson Laboratory