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| Caption | Histological analysis of testis sections reveals disruption to the seminiferous epithelium associated with a reduction in numbers of post-meiotic germ cells. (a) Testes from wild-type (+/+) and Katnal11H/Katnal11H animals appear similar at day 22 when examined by light microscopy. However, at day 35 disruption to the seminiferous epithelium is apparent in mutant testes, consistent with a significant reduction in seminiferous tubule diameter. At day 70, the seminiferous epithelium in the mutant testis appears disorganised and elongate spermatids (arrowed in WT) are almost absent. (b) The apparent reduction in elongate spermatid numbers was confirmed (arrows) using an antibody against PGK1/2 which marks post-meiotic germ cells from step 8. (c) The reduction in elongate spermatids was associated with a clear reduction in apical ectoplasmic specialisations (marked by Espin) in mutant testes (arrows in +/+). (+/+ = Wild-type; neg = no-primary control; Bar = 100 um unless stated). | ||||
| Copyright | This image is from Smith LB, PLoS Genet 2012 May;8(5):e1002697, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:185195 | ||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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