Phenotype Image Detail

Image

Caption

Ahr^b-1/Ahr^b-1 Aip^tm2.1Bra/Aip^tm2.1Bra Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 (Aip^fx/fxCre) mice are resistant to dioxin-induced hepatic damage. Mice were treated with corn oil or 64 ug/kg of dioxin and sacrificed 5 days after the single i.p. injection. The liver sections were stained with hematoxylin and eosin. Magnification, x100. Black arrowhead, the region of hydropic degeneration; asterisk, focal inflammation.

This image is from Nukaya M, J Biol Chem 2010 Nov 12;285(46):35599-605 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:166864

Associated
Alleles

Symbol	Name
Ahr^b-1	aryl-hydrocarbon receptor; b-1 variant
Aip^tm2.1Bra	aryl-hydrocarbon receptor-interacting protein; targeted mutation 2.1, Christopher A Bradfield
Speer6-ps1^{Tg(Alb-cre)21Mgn}	spermatogenesis associated glutamate (E)-rich protein 6, pseudogene 1; transgene insertion 21, Mark A Magnuson

Associated
Genotypes

Allelic Composition	Genetic Background
Ahr^b-1/Ahr^b-1 Aip^tm2.1Bra/Aip^tm2.1Bra Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	B6.Cg-Speer6-ps1^{Tg(Alb-cre)21Mgn} Aip^tm2.1Bra

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24