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Phenotype Image Detail
Image
Caption Impairment of angiogenesis by endothelial-specific deletion of Tmem100. (E) Endothelial-specific Tmem100 knockout embryos, Tmem100tm1.1Ysai/Tmem100tm2.1Ysai Tg(Tek-cre)1Ywa/0 (Tmem100fl/ko;Tek-Cre+), show pericardial effusion (arrow) and severe growth retardation at E10.5. There are no major vitelline vessels in endothelial-specific Tmem100 knockout yolk sac. (F) Impairment of cardiovascular morphogenesis is observed in endothelial cell-specific Tmem100 knockout mice. As in global Tmem100 null mice, paired dorsal aortas (da) are highly dilatated or narrow in Tmem100tm1.1Ysai/Tmem100tm2.1Ysai Tg(Tek-cre)1Ywa/0 embryos. Trabeculae of ventricular (v) myocardium are not well formed in Tmem100tm1.1Ysai/Tmem100tm2.1Ysai Tg(Tek-cre)1Ywa/0 embryos. Yolk sacs of endothelial-specific Tmem100 knockout mice show large lacunae by a detachment of endodermal (en) and mesodermal (me) layers. H&E staining is shown. (Scale bars: E, 200 um; F, a-d, 50 um; and F, e and f, 20 um.)
Copyright This image is from Somekawa S, Proc Natl Acad Sci U S A 2012 Jul 24;109(30):12064-9. Copyright 2012 National Academy of Sciences, U.S.A. J:186473
Associated
Alleles
Symbol Name
Tg(Tek-cre)1Ywa transgene insertion 1, Masashi Yanagisawa
Tmem100tm1.1Ysai transmembrane protein 100; targeted mutation 1.1, Yoshihiko Saito
Tmem100tm2.1Ysai transmembrane protein 100; targeted mutation 2.1, Yoshihiko Saito
Associated
Genotypes
Allelic Composition Genetic Background
Tmem100tm1.1Ysai/Tmem100tm2.1Ysai
Tg(Tek-cre)1Ywa/0 		involves: C57BL/6 * SJL
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory