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Phenotype Image Detail
Image
Caption Homozygous mutant Criptotm1.1Gmin/Criptotm1.1Gmin (F78A) embryos initiate gastrulation but subsequently arrest development. Morphology of wild-type (WT) embryos (A-D) and mutant litter mates (A'-D') dissected at 7.5 (A and A'), 8.5 (B and B'), 9.5 (C and C'), and 10.5 (D and D') dpc. Both anterior and posterior structures that are absent in Tdgf1 (cripto)-null mutants (Ding et al., 1998 ; Liguori et al., 2003 ) can be clearly recognized at up to 8.5 dpc but subsequently deteriorate (C' and D'). Bars, 40 um.
Copyright This image is from D'Andrea D, J Cell Biol 2008 Feb 11;180(3):597-605, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:186907
Associated
Alleles
Symbol Name
Criptotm1.1Gmin cripto, EGF-CFC family member; targeted mutation 1.1, Gabriella Minchiotti
Associated
Genotypes
Allelic Composition Genetic Background
Criptotm1.1Gmin/Criptotm1.1Gmin involves: 129S1/Sv * 129X1/SvJ * C57BL/6

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory