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| Caption | Cortex-specific double deletion of Fezf2tm1.1Nses (Fezf2) and Tbr1tm1Jlr (Tbr1) was achieved using the Tg(Emx1-cre)#Ito (Emx1-Cre) transgene. The retrograde tracer LMS was injected into the pons of neonatal mice of the indicated genotype. (A) In wild-type (Tbr1+/+; Fezf2+/+; Golli-Gfp) mice, retrogradely labeled neurons were positioned in L5 and did not express Golli-Gfp or ZFPM2 (open arrowheads). (B) In Tbr1tm1Jlr/Tbr1tm1Jlr Tg(Mbp-MAPT/EGFP)#Eja/0 (Tbr1-/-; Fezf2+/+; Golli-Gfp) mice, many L6 neurons expressing Golli-Gfp and ZFPM2 were retrogradely labeled by LMS (split arrowheads). (C) In Tbr1tm1Jlr/Tbr1tm1Jlr Fezf2tm1.1Nses/Fezf2tm1.1Nses Tg(Emx1-cre)#Ito/0 Tg(Mbp-MAPT/EGFP)#Eja/0 (Tbr1-/-; Fezf2 fl/fl; Emx1-cre; Golli-Gfp) cortex-specific double mutant, no Golli-Gfp+ or ZFPM2+ L6 neurons were retrogradely labeled. These data indicate a partial rescue of the Tbr1tm1Jlr/Tbr1tm1Jlr phenotype in the absence of cortical Fezf2 and suggest that the L6 CS projections of Tbr1tm1Jlr/Tbr1tm1Jlr depend on cortical Fezf2. (Scale bars: 200 um.) | ||||||||||
| Copyright | This image is from Han W, Proc Natl Acad Sci U S A 2011 Feb 15;108(7):3041-6. Copyright 2011 National Academy of Sciences, U.S.A. J:169221 | ||||||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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