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| Caption | Gt(ROSA)26Sortm1(tTA,tetO-Mir155)Fjsl/Gt(ROSA)26Sor+ Tg(Nes-cre)1Wmz/0 (mir-155LSLtTA) mice develop disseminated lymphoma. (A) Mutant mouse with ruffled fur and massively enlarged peripheral and axillary lymph nodes (arrowheads) (n=20). (C, D) Representative H&E sections from wild-type mice reveal distinct periarteriolar lymphocyte sheaths (PALS) in spleen and normal cortex and medullary in thymus; (n=20). (E, F) Representative H&E sections from mutant mouse spleen and thymus. Spleen and thymic parenchyma are effaced and replaced by a monotonous population of lymphoblasts (n=20). (G-J) Lymphocyte infiltration into liver, submandibular lymph nodes (SMLN), meninges of the brain (I, asterisk), paravertebral lymph nodes (J, arrows), and meninges of the spinal cord (J, arrowhead). Scale bars, 500 um (n=20). | ||||||
| Copyright | This image is from Babar IA, Proc Natl Acad Sci U S A 2012 Jun 26;109(26):E1695-704. Copyright 2012 National Academy of Sciences, U.S.A. J:185598 | ||||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/17/2024 MGI 6.24 |
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