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| Caption | Posterior view of a wild-type mouse illustrates the normal location of the aorta and efferent vessels (A). Posterior view of Ts(1716)65Dn/0 mouse shows an aberrant right subclavian artery (RSA) arising from the distal part of the aortic arch and describing a retrooesophagian loop (B). Haematoxylin-eosin staining of histological crosssections illustrates full septation of the ventricles with individualized valves in wild-type (C) while mutant heart cross-section shows an upper communication of the ventricles (D; arrow). This cardiovascular anomaly was observed in 1 in 18 mutant dead newborns. LSA, left subclavian artery; RSA, right subclavian artery; DA, descending aorta; RA, right atrium; LA, left atrium; RV, right ventricle; LV, left ventricle; Sept, septum; OT, outflow tract. Scale bars represent 1 mm in A, B and 400 um in C. | ||||
| Copyright | This image is from Raveau M, PLoS Genet 2012 May;8(5):e1002724, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:185269 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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