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| Caption | Phenotypic alterations in the axial skeleton of mice with a split HoxD cluster. Newborn animals were processed and stained for bone (alizarin red) and cartilage tissues (alcian blue). (A) Incidence of different lumbar vertebral formulae in wild-type, heterozygous (In(2Hoxd11;Itga6)1Ddu/+) and homozygous (In(2Hoxd11;Itga6)1Ddu/In(2Hoxd11;Itga6)1Ddu) mutant animals. L5/6 and L6/7 indicate unilateral transformations of the first sacral vertebrae. (B) Complete transformation of the first sacral vertebra into a lumbar identity (S1>L7) in a homozygous mutant (right), as compared to the L6 formula observed in wild-type specimen (left). (C) Misalignment of the first rib to the sternum (#) and fusions of sternebrae four and five (*) in a homozygous mutant. (D) Seventh cervical vertebrae (C7) of heterozygous and homozygous animals showing ectopic bony material protruding from the transverse processes (arrowheads). | ||||||
| Copyright | This image is from Tschopp P, PLoS Genet 2009 Mar;5(3):e1000398, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:146752 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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