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| Caption | (A) Radiography of an adult (12 week old) Galnt3tcal/Galnt3tcal male mouse revealed widespread subcutaneous soft tissue opacities (white arrows); two magnified areas (a and b) are shown to illustrate detailed views. (B) Von Kossa stained sections from mutant male mouse (36 week old) showing ectopic calcification in skin (arrow indicates mineralised panniculus fat); cutaneous striated muscle, heart, aorta, kidney and tongue submucosa. (C) Analysis of testes. Calcification was observed in the testicular arteries (left panel, von Kossa staining), and H&E sections (middle and right panels) of wild-type (WT) and mutant (TCAL) testis revealed disorganised seminiferous tubules and loss of spermatozoa in mutant mice. (D and E) TUNEL staining of WT and mutant testis and kidney sections, respectively, revealed increased apoptosis (green staining) in the tissues of mutant mice. | ||||
| Copyright | This image is from Esapa CT, PLoS One 2012;7(8):e43205, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:187064 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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