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| Caption | Spongiform degeneration of the neonatal PikfyveGt(AT0926)Wtsi/PikfyveGt(AT0926)Wtsi (PikfyveBeta-geo/Beta-geo) mouse heart. Saggital sections of neonatal wild-type (WT) and homozygous mutant mice stained with H&E. The atria (At), ventricles (V), and lung (L) of WT littermates exhibit normal morphology. At higher magnification, atrial and ventricular myocytes strongly stain with H&E. There is no apparent vacuolation. Homozygous mice have reduced H&E staining of atrial myocytes consistent with reduced myofibrillar content. In the homozygous mutants, both atria and ventricles have vacuoles (arrows), with a high level of vacuolation in the atria. Smaller vacuoles (arrowheads) give the myocytes (identified by heavily stained myofibrils (white arrow)) a foamy appearance. | ||||
| Copyright | This image is from Zolov SN, Proc Natl Acad Sci U S A 2012 Oct 23;109(43):17472-7. Copyright 2012 National Academy of Sciences, U.S.A. J:190368 | ||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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