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| Caption | Dusp6 is required for restoring the satellite cell (SC) pool during regeneration. Tibialis anterior (TA) and extensor digitorum longus (EDL) muscles of control and Dusp6tm1Jmol/Dusp6tm1Jmol mice were injured by a single cardiotoxin (CTX) injection and analyzed 30 days after the injury. (A) Single myofibers isolated from 30 day regenerated EDL muscles. Renewed Pax7+ SCs are located around host myofibers (arrows). The SC pool is increased 2.4-fold on regenerated mutant myofibers compared with control myofibers. (C) Cryosections of 30 day regenerated TA muscles. Immunolocalization of Pax7 and Laminin proteins allows visualization of sublaminar renewed SCs (arrows). The SC pool is increased 2-fold within regenerated mutant muscles compared with control muscles. No muscle defects were observed in mutant mice. Bars, 50 um. | ||||
| Copyright | This image is from Le Grand F, J Cell Biol 2012 Sep 3;198(5):815-32, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:190460 | ||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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