About   Help   FAQ
Phenotype Image Detail
Image
Caption Impaired ossification and matrix vesicle formation in Sp7tm1.1Rnis/Sp7tm1.1Rnis (deltaflox/deltaflox) mice. D, Von Kossa staining of tibia at E16.5 days in wild-type (WT) littermate and mutant mice. Scale bar; 100 um. Calcification of cartilage matrices is not observed. E, electron microscopy images of hypertrophic chondrocyte zone of WT and mutant mice. Right panels show higher magnification. Scale bar, 2 um. Matrix vesicles are not evident in the hypertrophic chondrocyte zone.
Copyright This image is from Nishimura R, J Biol Chem 2012 Sep 28;287(40):33179-90 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:191589
Associated
Alleles
Symbol Name
Sp7tm1.1Rnis Sp7 transcription factor 7; targeted mutation 1.1, Riko Nishimura
Associated
Genotypes
Allelic Composition Genetic Background
Sp7tm1.1Rnis/Sp7tm1.1Rnis involves: C57BL * C57BL/6NCrlj * CBA/JNCrlj * DBA

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/19/2024
MGI 6.24
The Jackson Laboratory