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Phenotype Image Detail
Image
Caption Impaired ossification and matrix vesicle formation in Sp7tm1.1Rnis/Sp7tm1.1Rnis (deltaflox/deltaflox) mice. D, Von Kossa staining of tibia at E16.5 days in wild-type (WT) littermate and mutant mice. Scale bar; 100 um. Calcification of cartilage matrices is not observed. E, electron microscopy images of hypertrophic chondrocyte zone of WT and mutant mice. Right panels show higher magnification. Scale bar, 2 um. Matrix vesicles are not evident in the hypertrophic chondrocyte zone.
Copyright This image is from Nishimura R, J Biol Chem 2012 Sep 28;287(40):33179-90 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:191589
Associated
Alleles
Symbol Name
Sp7tm1.1Rnis Sp7 transcription factor 7; targeted mutation 1.1, Riko Nishimura
Associated
Genotypes
Allelic Composition Genetic Background
Sp7tm1.1Rnis/Sp7tm1.1Rnis involves: C57BL * C57BL/6NCrlj * CBA/JNCrlj * DBA

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory