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| Caption | Abnormal mitochondrial network in Afg3l2tm1Arte/Afg3l2tm1Arte Tg(Pcp2-cre)2Mpin/0 (Afg312PC-KO) mice. Analyses were performed in animals of the shown genotypes crossed with Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+ mice. (A-D) The mitochondrial network is labeled with mt-YFP, (E and F) while Purkinje cell (PC) dendrites are decorated using an antibody against calbindin. (G and H) in merged images; pseudocolors were used; calbindin is in green, while mt-YFP is in red. Images in A and B show enlarged views of the boxes in C and D, respectively. (C) mt-YFP expression in control mice shows an elongated network of mitochondria (E and G) that follows the pattern of PC dendrites labeled with calbindin, (A) with mitochondria filling the entire space of large caliber dendrites. (D) In Afg3l2tm1Arte/Afg3l2tm1Arte Tg(Pcp2-cre)2Mpin/0 Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+ mice, the mitochondrial network shows initial fragmentation, with (B, F, and H) some large-caliber calbindin-stained dendrites depleted of mitochondria, which appear clustered. Scale bar: 20 um. | ||||||
| Copyright | This image is from Almajan ER, J Clin Invest 2012 Nov 1;122(11):4048-58 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:193564 | ||||||
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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