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| Caption | Rhotm2.1Kpal/Rhotm2.1Kpal (KK) mice undergo progressive retinal degeneration. (A) Representative 3D optical coherence tomography images of 2-month-old wild-type (WT) and Rhotm2.1Kpal/Rhotm2.1Kpal retinas. Scale bar: 20 um. The outer nuclear layer (ONL) was substantially thinner in retinas of homozygous mutant mice. (C) Plastic sections of retinas stained with toluidine blue from WT, heterozygous (EK) and homozygous (KK) mice at 1 and 4 months of age. Heterozygous mutant retina displayed an intermediate progression of retinal degeneration indicated by modest degeneration by 4 months of age that progressed to nearly complete loss of photoreceptors by 10 months of age. | ||||||
| Copyright | This image is from Zhang N, J Clin Invest 2013 Jan 2;123(1):121-37 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:194158 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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