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| Caption | Ultrastructural evidence of endoplasmic reticulum stress in the intestinal epithelium of Muc2wnn/Muc2wnn (Winnie) and Muc2eey/Muc2eey (Eeyore) mice. Semi-thin sections from resin embedded large intestine of wild-type (WT) (A),Winnie (E), and Eeyore (I) mice and small intestine of WT (M), Winnie (P), and Eeyore (S) mice stained with toluidine blue. Transmission electron micrographs from the large intestine (B-D, F-H, J-L, and V) and small intestine (N, O, Q, R, T, U, W, and X) of WT (B-D, N, and O), Winnie (F-H, Q, R, and V), and Eeyore (J-L, T, and U) mice. Note the reduced size of goblet cell thecae (indicated by a T) containing stored mucin granules and the presence of vacuoles (indicated by a V) surrounded by rough endoplasmic reticulum (RER) in Winnie and Eeyore. Other abbreviations: G, Paneth cell granule; GA, Golgi apparatus; L, lumen. Scale bars 40 um (A, E, and I), 20 um (L, O, and R), 5 um (B, F, J, and U), 2 um (C, G, K, M, P, S, and V), 1 um (W), 50 nm (D, H, L, N, Q, and T). | ||||||
| Copyright | This image is from Heazlewood CK, PLoS Med 2008 Mar 4;5(3):e54, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:194148 | ||||||
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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