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Phenotype Image Detail
Image
Caption Increased grade of oligodendroglioma in Gt(ROSA)26Sortm1(RICTOR)Jger/Gt(ROSA)26Sortm1(RICTOR)Jger Tg(GFAP-EGFR*,-lacZ)#Agu/0 Tg(GFAP-cre)25Mes/0 mice. H&E sections of a typical tumor displayed increased regions of necrosis and cells with pyknotic nuclei. Increased endothelial proliferation was also observed consistent with anaplastic oligodendroglioma in humans (grade 3 WHO).
Copyright This image is from Bashir T, PLoS One 2012;7(10):e47741, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:192206
Associated
Alleles
Symbol Name
Gt(ROSA)26Sortm1(RICTOR)Jger gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Joseph Gera
Tg(GFAP-cre)25Mes transgene insertion 25, Albee Messing
Tg(GFAP-EGFR*,-lacZ)#Agu transgene insertion, Abhijit Guha
Associated
Genotypes
Allelic Composition Genetic Background
Gt(ROSA)26Sortm1(RICTOR)Jger/Gt(ROSA)26Sortm1(RICTOR)Jger
Tg(GFAP-cre)25Mes/0
Tg(GFAP-EGFR*,-lacZ)#Agu/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory