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Phenotype Image Detail
Image
Caption Nrltm1Jcco/Nrltm1Jcco (Nrlfl/fl) retinas are indistinguishable from wild-type (Nrl+/+) retinas by H&E histology and in situ hybridization for rod and cone transcripts. Germ-line recombination of the floxed Nrl alleles via Sox2-Cre, Nrltm1.1Jcco/Nrltm1.1Jcco (NrlCKO/CKO) recapitulates the Nrltm1Asw/Nrltm1Asw (Nrl-/-) phenotype in which adult rods are reprogrammed into cone-like cells. (Scale bar, 50 um.)
Copyright This image is from Montana CL, Proc Natl Acad Sci U S A 2013 Jan 29;110(5):1732-7. Copyright 2013 National Academy of Sciences, U.S.A. J:193697
Associated
Alleles
Symbol Name
Nrltm1.1Jcco neural retina leucine zipper gene; targeted mutation 1.1, Joseph C Corbo
Nrltm1Asw neural retina leucine zipper gene; targeted mutation 1, Anand Swaroop
Associated
Genotypes
Allelic Composition Genetic Background
Nrltm1.1Jcco/Nrltm1.1Jcco involves: C57BL/6 * CBA
Nrltm1Asw/Nrltm1Asw involves: 129S1/Sv * 129X1/SvJ
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory