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Phenotype Image Detail
Image
Caption Rod reprogramming prevents retinal degeneration in Rhotm1Jlem/Rhotm1Jlem Nrltm1Jcco/Nrltm1Jcco Tg(CAG-cre/Esr1*)5Amc/0 mice. Control is Rhotm1Jlem/Rhotm1Jlem Nrltm1Jcco/Nrl+ Tg(CAG-cre/Esr1*)5Amc/0 + 4-OHT and acute Nrl KO is Rhotm1Jlem/Rhotm1Jlem Nrltm1Jcco/Nrltm1Jcco Tg(CAG-cre/Esr1*)5Amc/0 + 4-OHT. (B) H&E and antibody staining show increased preservation of the outer nuclear layer (ONL) and cone opsin expression in Rhotm1Jlem/Rhotm1Jlem Nrltm1Jcco/Nrltm1Jcco Tg(CAG-cre/Esr1*)5Amc/0 mice relative to controls. (Scale bar, 50 um.)
Copyright This image is from Montana CL, Proc Natl Acad Sci U S A 2013 Jan 29;110(5):1732-7. Copyright 2013 National Academy of Sciences, U.S.A. J:193697
Associated
Alleles
Symbol Name
Nrltm1Jcco neural retina leucine zipper gene; targeted mutation 1, Joseph C Corbo
Rhotm1Jlem rhodopsin; targeted mutation 1, Janis Lem
Tg(CAG-cre/Esr1*)5Amc transgene insertion 5, Andrew P McMahon
Associated
Genotypes
Allelic Composition Genetic Background
Nrltm1Jcco/Nrltm1Jcco
Rhotm1Jlem/Rhotm1Jlem
Tg(CAG-cre/Esr1*)5Amc/0 		involves: 129S4/SvJae * C57BL/6 * CBA
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory