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Caption | ABHD12 disruption causes age-dependent increases in microglial activation in the mouse brain. (A-C) Representative images of Iba1 immunostaining for microglia in the cerebellum of 18-month-old (A), 12-month-old (B), and 6-month-old (C) wild-type (ABHD12+/+) and Abhd12tm1Crv/Abhd12tm1Crv (ABHD12-/-) mice. (D-F) Quantifying the number of enlarged cells (>200 um2) revealed significantly more activated microglia in cerebellar sections from 18-month-old (D) and 12-month-old (E) mutant mice compared with wild-type mice. No genotype differences were observed at 6 months of age (F). Data represent the averages +/- SEM. ***P < 0.001 (n = 3-4 per genotype per age group). (Scale bar, 100 um.) | ||||
Copyright | This image is from Blankman JL, Proc Natl Acad Sci U S A 2013 Jan 22;110(4):1500-5. Copyright 2013 National Academy of Sciences, U.S.A. J:193716 | ||||
Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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