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| Caption | Hematoxylin and Eosin (H&E) staining of cochlear sections from Myo7a mutant mice at 8 and 12 weeks old. (A-F) wild-type (Myo7a+/+), (G-L) Myo7aewaso/Myo7aewaso (Myo7aI487N/I487N) and (M-R) Myo7admbo2/Myo7admbo2 (Myo7aF947I/F947I) mice at the apical, middle and basal levels. Normal cochlear morphology shows an intact organ of Corti and the presence of a tunnel containing inner and outer hair cells and intact spiral ganglion and stria vascularis (B). Early signs of cochlea degeneration are evident in the basal region of Myo7aewaso/Myo7aewaso cochleae by 8 weeks of age (I), where the Organ of Corti has collapsed (arrow in I). Complete lack of cellular architecture along the basilar membrane at the mid level is evident in this strain by 12 weeks (arrowhead in K). The cellular architecture in Myo7admbo2/Myo7admbo2 mutants is largely normal at both 8 and 12 weeks. In both mutant strains the spiral ganglion and the stria vascularis were normal at 8 and 12 weeks of age. RM, Reisner's membrane; SG, spiral ganglion; OHC, outer hair cells; IHC, inner hair cells; OC, organ of Corti; BM, basilar membrane; SV, stria vascularis. Scale bar: 100 um. | ||||||
| Copyright | This image is from Miller KA, PLoS One 2012;7(12):e51284, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195666 | ||||||
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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