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| Caption | Loss of Krt7 is associated with hyperproliferation but not hyperplasia of the bladder urothelium. Immunohistochemistry of bladder sections from wild-type (A, D), heterozygous (B, E) and homozygous Krt7tm1Whim mice (C, F) stained with a rabbit polyclonal antibody to Krt7 (A, B, C) and mouse monoclonal antibody MM1 to the cell proliferation marker Ki-67 (D, E, F). Arrowheads and insets in panels D and E indicate Ki-67 positive nuclei in wild-type (D) and heterozygous (E) bladder. More Ki-67 positive cell nuclei can be seen in the bladder of Krt7tm1Whim/Krt7tm1Whim (KO) mice (arrowheads in F). Scale bars = 50 um. | ||||
| Copyright | This image is from Sandilands A, PLoS ONE 2013;8(5):e64404, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:196575 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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