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| Caption | The Dscam3J mutation reproduces some aspects of the Dscam null retina. A-C, Retinal sections from wild-type (Dscam+/+), Dscam2J/Dscam2J (Dscam2J/2J) and Dscam3J/Dscam3J (Dscam3J/3J) mice were stained with hematoxylin and eosin. In the wild-type retina (A) the three cellular layers are neatly stacked and the synapse containing plexiform layers do not intrude within the cellular layers. B, Cell number is increased in the Dscam2J/Dscam2J retina, with ectopic cells located in the inner plexiform layer, which projects into the inner nuclear layer. C, The Dscam3J/Dscam3J retina is hypercellular; however, cellular lamination is more neatly organized compared to the Dscam2J/Dscam2J retina. D-F, Retinal ganglion cell spacing and arborization is disrupted in both the Dscam2J/Dscam2J and Dscam3J/Dscam3J retina compared to wild-type. G-I, Amacrine cell spacing and arborization is disrupted in the Dscam2J/Dscam2J retina but this degree of disruption is not observed in the Dscam3J/Dscam3J retina (I). J, Occasional loose fasciculation of Dscam3J/Dscam3J dopaminergic cell neurites was observed (arrows). K and L, Wild-type and Dscam3J/Dscam3J retinas were stained with antibodies to bNOS, to detect bNOS-positive amacrine cells. The number of bNOS positive amacrine cells is increased in the Dscam3J/Dscam3J retina. The scale bar in (A-C) is equivalent to 132 um. The scale bar in (I) is equivalent to 320 um in D-I and K and L, and 100 um in J. | ||||||
| Copyright | This image is from Schramm RD, PLoS One 2012;7(12):e52652, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195831 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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