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| Caption | Endogenous Gja3 influences cataract formation caused by the Gja8R205G mutation. (A) Lens photos of wild-type (Gja8+/+ Gja3+/+), Gja8R205G/Gja8+ (Gja8R205G/+Gja3+/+), Gja8R205G/Gja8R205G (Gja8R205G/R205GGja3+/+), and double mutant Gja8R205G/Gja8R205G Gja3tm1Scr/Gja3tm1Scr (Gja8R205G/R205GGja3-/-) mice at the age of 3 weeks. These mutant lines were bred into the C57BL/6J strain background. While the Gja8R205G/Gja8R205G lens revealed vacuole-like defects in the lens periphery (indicated by a white arrow), the double Gja8R205G/Gja8R205G Gja3tm1Scr/Gja3tm1Scr mutant lens showed a clear lens periphery (indicated by a white arrow). Scale bar, 1 mm. (B) Histological sections of Gja8R205G/Gja8R205G mutant and Gja8R205G/Gja8R205G Gja3tm1Scr/Gja3tm1Scr mutant lenses from 3-week-old littermates. The homozygous Gja8R205G/Gja8R205G lens section showed disorganized peripheral fibers with vacuoles or enlarged extracellular spaces (labeled with asterisk) near the lens bow region (indicated by an arrowhead), while the double Gja8R205G/Gja8R205G Gja3tm1Scr/Gja3tm1Scr mutant lens section shows organized and elongated periphery fiber cells at the bow region (indicated by an arrowhead). Scale bar, 50 um. | ||||||
| Copyright | This image is from Xia CH, PLoS One 2012;7(12):e52894, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195727 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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