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Phenotype Image Detail
Image
Caption Smg1Gt(AG0297)Wtsi/Smg1+ mice have decreased viability compared with wild-type (WT) littermates. (A) Kaplan-Meier survival plot shows the significantly decreased viability of heterozygous mutant mice compared with WT littermates. Statistical significance was determined using Prism 5 software (GraphPad Software). H&E staining of paraffin-embedded sections shows key pathological findings observed in heterozygous mice [lymphomas (B), chronic inflammation (C), papillary adenocarcinoma (D), and steatosis (E)] and WT tissues for comparison [lung (F), spleen (G), and liver (H)].
Copyright This image is from Roberts TL, Proc Natl Acad Sci U S A 2013 Jan 22;110(4):E285-94. Copyright 2013 National Academy of Sciences, U.S.A. J:193626
Associated
Alleles
Symbol Name
Smg1Gt(AG0297)Wtsi SMG1 nonsense mediated mRNA decay associated PI3K related kinase; gene trap AG0297, Wellcome Trust Sanger Institute
Associated
Genotypes
Allelic Composition Genetic Background
Smg1Gt(AG0297)Wtsi/Smg1+ involves: 129P2/OlaHsd * C57BL/6

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory