Phenotype Image Detail

Image

Caption

Loss of Wasl leads to hypoplasia and loss of glomeruli and proximal tubules. (A-C) PAS staining (P0) of wild-type and Wasl^tm2Sbs/Wasl^tm2Sbs Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ (N-Wasp^CM-/-) kidneys showing hypoplasia in mutants. (D,E) Sections of P0 kidneys processed for Podocin analysis shows a strong decrease in glomeruli formation in mutant kidneys. Average count and standard deviation from four controls and four mutants are shown in F. ***p<0.0001. (G-I) Sections of P0 kidneys processed for LTL and Calbindin staining shows reduced proximal tubule formation in mutant kidneys. Scale bars represent 100 um (A-E), 100 um (G-I).

This image is from Reginensi A, PLoS Genet 2013 Mar;9(3):e1003380, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195266

Associated
Alleles

Symbol	Name
Six2^{tm1(tTA,tetO-EGFP/cre)Amc}	sine oculis-related homeobox 2; targeted mutation 1, Andrew P McMahon
Wasl^tm2Sbs	WASP like actin nucleation promoting factor; targeted mutation 2, Scott B Snapper

Associated
Genotypes

Allelic Composition	Genetic Background
Wasl^tm2Sbs/Wasl^tm2Sbs Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺	involves: 129 * C57BL/6J

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