Phenotype Image Detail

Image

Caption

Histology of Pkd1^tm1.1Pcha/Pkd1^tm1Shh (Pkd1^RC/del2) mice highlights early-onset and rapidly progressive cystic disease. Representative Masson Trichrome sections of mutant and wild-type (WT) kidneys from E14.5 to P180 Kidney cysts were clearly visible as early as E16.5 (a few cysts were present at E15.5) and rapidly increased in number/size with age. Glomerular cysts were present as early as E16.5 (insets). The kidneys of animals with longer survival (P180) were highly fibrotic, with little obvious healthy tissue. Scale bars: 100 um (E14.5 to P1); 500 um (P12); 750 um (P25 and P180); 50 um (insets).

This image is from Hopp K, J Clin Invest 2012 Nov 1;122(11):4257-73 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:193544

Associated
Alleles

Symbol	Name
Pkd1^tm1.1Pcha	polycystin 1, transient receptor potential channel interacting; targeted mutation 1.1, Peter Harris
Pkd1^tm1Shh	polycystin 1, transient receptor potential channel interacting; targeted mutation 1, Shigeo Horie

Associated
Genotypes

Allelic Composition	Genetic Background
Pkd1^tm1Shh/Pkd1^tm1.1Pcha	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24