Phenotype Image Detail

Image

Caption

Illustration of disease progression and variation in Pkd1^tm1.1Pcha/Pkd1^tm1.1Pcha (Pkd1^RC/RC) mice. (A) Gross images of wild-type (WT) and homozygous mutant kidneys at 3, 6, 9 and 12 months. Macroscopic cysts become visible by 6 months. Ruler shows the SI unit cm. (B) Masson Trichrome stained kidney histology sections of homozygous mice used for physiological and histological analysis. The illustration highlights the observed disease variability among animals at the same age, and the progressive disease severity throughout aging in these outbred animals. Scale bars = 1 mm.

This image is from Hopp K, J Clin Invest 2012 Nov 1;122(11):4257-73 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:193544

Associated
Alleles

Symbol	Name
Pkd1^tm1.1Pcha	polycystin 1, transient receptor potential channel interacting; targeted mutation 1.1, Peter Harris

Associated
Genotypes

Allelic Composition	Genetic Background
Pkd1^tm1.1Pcha/Pkd1^tm1.1Pcha	involves: 129S1/Sv * C57BL/6

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