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| Caption | Histology of a representative example of a typical pituitary tumor in Gt(ROSA)26Sortm1(CAG-Bmi1,-EGFP)Nki/Gt(ROSA)26Sor+ Tg(Gfap-cre)2Brn/0 (Gcre;Bmi1LSL) mice. (A) Average location of pituitary tumors observed in mutant mice showing localization to the pituitary gland (n = 6). Localization is based on Allen's mouse brain database. (B) H&E staining of a coronal section of the brain showing a typical pituitary tumor. Immunohistochemistry shows expression analysis of (C) Chromogranin A, (D) adrenocorticotropic hormone ACTH, (E) Growth Hormone hGH, (F) Prolactin PRL, (G) Thyroid Stimulating Hormone TSH, (H) cytokeratin 8/18 CAM5.2 and (I) CD56/NCAM. Of these markers, ACTH is clearly positive in this tumor. Electron microscopy (EM) shows secretory vesicles (indicated by the arrowheads) in mutant tumors (J, K) in a similar way as observed in human tumors (M, N). Ki67 is clearly positive in this tumor (L). Immunohistochemistry of human pituitary adenomas show over expression of BMI1, which is visualized by a nuclear signal (O). Bars, 100 um unless otherwise noted. | ||||||
| Copyright | This image is from Westerman BA, PLoS One 2012;7(5):e35943, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:187257 | ||||||
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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