Phenotype Image Detail

Image

Caption

Loss of Mob1a/Mob1b promotes tumorigenesis. (A and B) Tumor types arising in Mob1a^tm1.2Asuz/Mob1a^tm1.2Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b⁺ (Mob1a^delta/delta Mob1b^tr/+) or Mob1a^tm1.2Asuz/Mob1a⁺ Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} (Mob1a^delta/+ Mob1b^tr/Mob1b^tr) mice. (A) Macroscopic or microscopic photographs of the indicated gross or H&E-stained tumors in mutant mice. Yellow arrows, tumor masses. Scale bars: 100 um.

This image is from Nishio M, J Clin Invest 2012 Dec 3;122(12):4505-18 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:193981

Associated
Alleles

Symbol	Name
Mob1a^tm1.2Asuz	MOB kinase activator 1A; targeted mutation 1.2, Akira Suzuki
Mob1b^{Gt(CC0690)Wtsi}	MOB kinase activator 1B; gene trap CC0690, Wellcome Trust Sanger Institute

Associated
Genotypes

Allelic Composition	Genetic Background
Mob1a^tm1.2Asuz/Mob1a^tm1.2Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b⁺	involves: 129P2/OlaHsd * C57BL/6
Mob1a^tm1.2Asuz/Mob1a⁺ Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi}	involves: 129P2/OlaHsd * C57BL/6

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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