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Phenotype Image Detail
Image
Caption Aortic root atherosclerosis. A) Representative trichrome-stained images of lesions in the aortic root and lesion area measurements. Left image: Apoetm1Unc/Apoetm1Unc (11betaHSD1+/+/ApoE-/-) aortic root. Right image: Apoetm1Unc/Apoetm1Unc Hsd11b1tm1Lex/Hsd11b1tm1Lex (11betaHSD1-/-/ApoE-/-) aortic root. Asterisks denote regions of acellular necrotic debris. Plot:Lesion area measurements from trichrome-stained images in Apoetm1Unc/Apoetm1Unc (n = 10) and Apoetm1Unc/Apoetm1Unc Hsd11b1tm1Lex/Hsd11b1tm1Lex (n = 9) male mice. B) Intraplaque necrotic areas. Left image: Apoetm1Unc/Apoetm1Unc aortic root plaque. Right image: Apoetm1Unc/Apoetm1Unc Hsd11b1tm1Lex/Hsd11b1tm1Lex aortic root plaque. Asterisks denote necrotic areas within lesions. Acellularity and features of crystalline clefts were used to demarcate necrotic regions. Plot: Necrotic core area measurements from trichrome-stained images in Apoetm1Unc/Apoetm1Unc (n = 10) and Apoetm1Unc/Apoetm1Unc Hsd11b1tm1Lex/Hsd11b1tm1Lex (n = 9) male mice. C) Macrophage staining via CD68 immunohistochemistry. Left image: Apoetm1Unc/Apoetm1Unc aortic root. Right image: Apoetm1Unc/Apoetm1Unc Hsd11b1tm1Lex/Hsd11b1tm1Lex aortic root. Arrows denote CD68 positive staining. Plot: CD68 positive stained area measurements in Apoetm1Unc/Apoetm1Unc (n - 10) and Apoetm1Unc/Apoetm1Unc Hsd11b1tm1Lex/Hsd11b1tm1Lex (n = 9) male mice. Significance vs. control: *p<= 0.05. Data are pooled from two independently run in vivo studies.
Copyright This image is from Garcia RA, PLoS One 2013;8(2):e53192, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:199430
Associated
Alleles
Symbol Name
Apoetm1Unc apolipoprotein E; targeted mutation 1, University of North Carolina
Hsd11b1tm1Lex hydroxysteroid 11-beta dehydrogenase 1; targeted mutation 1, Lexicon Genetics
Associated
Genotypes
Allelic Composition Genetic Background
Apoetm1Unc/Apoetm1Unc
Hsd11b1tm1Lex/Hsd11b1tm1Lex
B6.129-Hsd11b1tm1Lex Apoetm1Unc

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory