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Phenotype Image Detail
Image
Caption Embryonic and perinatal mortality in Ptentm1Hwu/Ptentm1Hwu Twist2tm1.1(cre)Dor/Twist2+ (Ptenf/f;Dermo-Cre) mice due to vascular defects. (A-D) Gross appearance of representative control (A,C) and mutant (B,D) E15.5 (A,B) and E18.5 (C,D) embryos. Note skin pallor in mutants caused vascular failure (B) with hemorrhages at E18.5 (D). (E) Mutant mice (left) at birth with cyanosis.
Copyright This image is from Tiozzo C, J Clin Invest 2012 Nov 1;122(11):3862-72 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:192736
Associated
Alleles
Symbol Name
Ptentm1Hwu phosphatase and tensin homolog; targeted mutation 1, Hong Wu
Twist2tm1.1(cre)Dor twist basic helix-loop-helix transcription factor 2; targeted mutation 1.1, David M Ornitz
Associated
Genotypes
Allelic Composition Genetic Background
Ptentm1Hwu/Ptentm1Hwu
Twist2tm1.1(cre)Dor/Twist2+
B6.129-Twist2tm1.1(cre)Dor Ptentm1Hwu

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory