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Caption | (A-D) Diffuse pattern of Prdm1 expression in E6.5 (B) and E7.0 (D) Wnt3tm1Brd/Wnt3tm1Brd (Wnt3-/-) embryos and absence of the cluster of Prdm1-positive primordial germ cell (PGC) progenitors compared with that in Wnt3tm1Brd/Wnt3+ (Wnt3+/-) (A, C) counterparts. (E-J) Absence of PGCs that were marked by AP (E, F), Dppa3 (G, H) and Ifitm3 (I, J) in Wnt3tm1Brd/Wnt3tm1Brd embryos compared with that in Wnt3tm1Brd/Wnt3+ embryos (arrowhead: PGCs). (E, F, I, J) E7.75 and (G, H) E8.0 embryos. (K-M') Reduced number of Dppa3-expressing PGCs in Ctdnep1tm1Ryn/Ctdnep1+ Wnt3tm1Brd/Wnt3+ (Dullard+/-; Wnt3+/-) embryos. (K-M) Bright-field images of E7.75 (K) Wnt3tm1Brd/Wnt3+ and (L, M) Ctdnep1tm1Ryn/Ctdnep1+ Wnt3tm1Brd/Wnt3+ embryos (posterior view). (K'-M') Dppa3/Pgc7/Stella immunostaining of PGCs in the posterior region of embryos shown in K-M. Scale bars = 100 um. | ||||||
Copyright | This image is from Tanaka SS, PLoS One 2013;8(3):e57428, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:199855 | ||||||
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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